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Abstract
Lipid droplets (LDs) are crucial for cellular processes like energy balance and autophagy through their interaction with mitochondria.
- LD-mitochondria interactions are regulated by specialized membrane contact sites and proteins, including Perilipin family proteins, Mitofusin2, and Rab GTPases.
- These interactions function as a regulatory hub for fatty acid transport, metabolic adaptation, and stress responses.
- This communication allows cells to switch between storing lipids and burning fatty acids based on metabolic signals.
- Disruption of LD-mitochondria communication may impair lipid utilization and mitochondrial function, leading to increased oxidative stress and ferroptosis.
- Such dysfunction is linked to the progression of metabolic disorders, cardiovascular diseases, and neurodegenerative diseases.
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