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The association between lipid levels and leukocyte count: A cross-sectional and longitudinal analysis of three large cohorts
How blood fat levels are linked to white blood cell counts over time in three large groups
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Abstract
Cross-sectional data from 27,566 participants indicate that lower high-density lipoprotein (HDL) cholesterol is associated with a 0.9% lower and higher triglycerides with a 0.3% higher leukocyte count per 10 mg/dL increase.
- Lower HDL cholesterol levels are linked to higher leukocyte counts.
- Higher triglyceride levels may also be associated with increased leukocyte counts.
- Similar associations were observed in the Treating to New Targets (TNT) trial but not in the Korean National Health and Nutrition Survey (KNHANES).
- In the TNT trial, a 10 mg/dL increase in triglycerides over one year correlated with a 0.09 × 10/μL increase in leukocyte count.
- These findings suggest weak yet noteworthy associations between dyslipidaemia and leukocytosis.
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