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Abstract
Changes in lipid species levels may drive or contribute to the senescent phenotype in brain cells.
- Senescence is associated with irreversible growth arrest and metabolic changes in neurons and other brain cells.
- Alterations in lipid metabolism, including fatty acids and cholesterol, are linked to the senescence-associated secretory phenotype (SASP).
- Accumulation of lipid droplets can disrupt membrane dynamics and produce bioactive lipid mediators.
- Specific patterns of lipid dysregulation are observed in neurons, astrocytes, microglia, and other glial cells during senescence.
- Mitochondrial dysfunction may interact with lipid metabolism in the context of cellular senescence.
- Therapeutic strategies targeting lipid metabolic pathways could modulate neural senescence and age-related brain disorders.
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