International journal of nanomedicine

Using Lipid Nanoparticles to Treat Brain Fungal Infections and Support the Immune Response

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Abstract

Approximately 112,000 deaths from neuromycoses occur annually, with 19% linked to AIDS.

  • Neuromycoses are fungal infections that impact the central nervous system.
  • Conventional antifungal treatments face challenges like limited penetration of the blood-brain barrier and increasing resistance.
  • Lipid nanoparticles may enhance the effectiveness of antifungal treatments while also modulating immune responses.
  • Current knowledge on lipid nanoparticles includes their design, drug delivery methods, and interactions within the body.
  • Research outlines a roadmap for using lipid nanoparticles in next-generation treatments for neuromycoses.

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