MicroRNA-192 in fat nanoparticles reduces inflammation and boosts vaccine response in older mice

miR-192-loaded lipid nanoparticles may improve vaccine responses in aged mice by suppressing inflammation that weakens antibody production.

This preclinical LNP formulation and mouse vaccination study found that IL-6 and TNF-alpha at the vaccination site reduced antigen-specific antibodies, while miR-192 LNPs downregulated inflammatory cytokine and JAK-STAT signaling and enhanced responses, especially in aged mice.

The evidence is limited to mouse and transcriptomic experiments, so human vaccine efficacy and safety are not established by the abstract.