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Lipid nanoparticle-encapsulated microRNA-192: An anti-inflammatory adjuvant that enhances vaccine efficacy in aged mice
MicroRNA-192 in fat nanoparticles reduces inflammation and boosts vaccine response in older mice
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Abstract
Lipid nanoparticles encapsulating miR-192 significantly enhanced vaccine efficacy in aged mice.
- Excessive proinflammatory cytokines, like IL-6 and TNF-α, were found to reduce antibody production after vaccination.
- miR-192 demonstrated strong anti-inflammatory effects, improving vaccine performance in older subjects.
- Transcriptomic analyses indicated that miR-192 downregulated several pro-inflammatory cytokines that negatively affect vaccine responses.
- miR-192 inhibited critical components of the JAK-STAT signaling pathway, which is important for cytokine signaling in immune cells.
- These findings suggest that targeting inflammation with microRNA-based approaches could enhance vaccination outcomes in the elderly.
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