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Abstract
The engineered mRNA lipid nanoparticle vaccine induced high levels of antibodies and T cell responses in mice against influenza A.
- The mRNA vaccine included a cytokine adjuvant and influenza A hemagglutinin antigen for intradermal vaccination.
- High levels of humoral antibodies and systemic T cell responses were observed against heterologous influenza antigens.
- Immunized mice were protected against influenza A viral infections.
- Early germinal center reactions in draining lymph nodes were triggered, promoting antibody-secreting B cell responses.
- Two different adjuvant mRNAs enhanced both humoral and cellular immune responses in mice.
- Intramuscular immunizations led to significant lung tissue-resident T cells.
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