Recent Advancements in Lipid Nanoparticles-Based Phytoactives Delivery Systems for Neurodegenerative Diseases

Sep 2, 2025International journal of nanomedicine

New Developments in Plant-Based Lipid Nanoparticles for Delivering Treatments in Brain Degeneration

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Abstract

encapsulated in may enhance their effectiveness in targeting neuronal degeneration associated with neurodegenerative diseases.

Neurodegenerative diseases like Alzheimer's and Parkinson's currently lack definitive treatments to modulate neuronal degeneration.
Phytochemicals, which are secondary metabolites from plants, show promise for managing neurodegenerative disorders due to their ability to target neurons.
The large size and polar nature of phytochemicals limit their ability to cross the , which separates blood from the brain.
Encapsulation of phytochemicals in lipid nanoparticles has been shown to improve their stability and facilitate their passage through the blood-brain barrier.
Using lipid nanoparticles for phytochemical delivery could result in better accumulation in brain tissue and more effective neuroprotective effects compared to unencapsulated forms.

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Neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, pose a significant and continuous burden on the healthcare system, urging the search for innovative therapeutical approaches targeting the central nervous system. Nowadays, no definitive treatment can effectively modulate the neuronal degeneration associated with such diseases. The current line of therapies is primarily symptomatic and suffers several drawbacks. Among these, are emerging for their potential in the management of neurodegenerative disorders. Indeed, plants produce secondary metabolites that provide defensive functions against abiotic and biotic stresses. These metabolites can target the neurons and represent a promising therapeutic intervention for neurological disorders. However, the polar nature of phytochemicals and their large size hinder their passage through the , a selective barrier separating blood and the brain. Emerging studies have shown that the therapeutic efficiency of phytochemicals has been enhanced following their encapsulation with engineered nanocarriers such as . Recent research indicates that delivering phytochemicals through lipid nanoparticles improves their physiological stability, promotes their passage across the blood-brain barrier, and enhances their accumulation in brain tissue-resulting in more effective neuroprotective effects than their free, unencapsulated form. Hence, the aim of the present review is to highlight the application of lipid nanoparticles as carriers for phytoactives with neuroprotective properties, discuss the current challenges associated with such nanocarriers, and provide insights into potential future research work.

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Recent Advancements in Lipid Nanoparticles-Based Phytoactives Delivery Systems for Neurodegenerative Diseases

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