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Delivery of lipid nanoparticles containing small interfering RNA targeting transmembrane serine protease 4 in a human gastric cancer model using nude mice
Using fat-based particles to deliver gene-silencing RNA targeting a membrane enzyme in a human stomach cancer model in mice
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Abstract
Over-expression of (TMPRSS4) is associated with poor prognosis in gastric cancer patients.
- TMPRSS4 promotes processes that contribute to cancer spread and poor outcomes.
- (LNPs) enhanced accumulation of anti-TMPRSS4 small interfering RNA (siRNA) in tumor tissue compared to unprotected siRNA.
- Mice treated with a combination of anti-TMPRSS4-siRNA loaded LNPs and fluorouracil showed a significant reduction in tumor growth compared to those treated with fluorouracil alone.
- The findings suggest that anti-TMPRSS4-siRNA loaded LNPs could be a potential new therapy for gastric cancer.
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Key numbers
487.4 ± 331.7 mg
Reduction
Weight of tumors in mice treated with -siTMPRSS4 and .
962.6 ± 435.5 mg
Control
Weight of tumors in control group receiving alone.
93%
Accumulation
Encapsulation efficiency of in .