Full text is available at the source.
Abstract
Lipid sensing may coordinate the release of multiple hormones that regulate satiety and glucose levels.
- Lipid sensing triggers the release of hormones from the small intestine and kidney.
- Key hormones involved include cholecystokinin, peptide YY, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide.
- Dysregulation of these lipid sensing pathways is associated with obesity and type 2 diabetes mellitus.
- Interventions such as bariatric surgery and gut microbiota modulation may restore hormone secretion and improve metabolism.
- An endocrine and neural axis governed by lipid sensing is proposed to influence energy balance.
Simplified