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Abstract
The environmentally adjusted metabolic age score (EAmAge) was derived from a cohort of 10,339 individuals.
- EAmAge isolates intrinsic ageing biology relevant to neurodegeneration and chronic disease by statistically removing major environmental influences.
- Validation of EAmAge was conducted across three independent cohorts totaling 9,835 individuals.
- Stronger and more consistent associations were observed between EAmAge and incident Alzheimer's disease-related dementia, cardiovascular events, and all-cause mortality compared to an unadjusted lipidomic age model.
- EAmAge was linked to Alzheimer's disease-related biomarkers, including amyloid burden, reduced glucose metabolism, and hippocampal atrophy.
- This biomarker may improve risk stratification by disentangling intrinsic metabolic ageing from environmental confounding.
Simplified
Longevity & Aging