International journal of obesity (2005)

Liraglutide 3.0 mg's effects in people with obesity and moderate to severe sleep apnea

Updated

Abstract

After 32 weeks, liraglutide 3.0 mg led to a mean reduction of 12.2 events h(-1) in the apnea-hypopnea index (AHI) compared to 6.1 events h(-1) with placebo.

  • Liraglutide is associated with a greater mean percentage weight loss of -5.7% compared to -1.6% with placebo.
  • The estimated treatment difference for weight loss is -4.2% with a confidence interval of -5.2 to -3.1%.
  • A significant link exists between weight loss and improvement in OSA-related measurements.
  • Statistically significant reductions in glycated hemoglobin and systolic blood pressure were observed with liraglutide.
  • The safety profile of liraglutide 3.0 mg is similar to lower doses of the medication.

Simplified

Key numbers

-6.1 events h(-1)
Reduction in AHI
Mean change in AHI with liraglutide vs. placebo after 32 weeks
-5.7%
Weight Loss
Mean percentage weight loss with liraglutide vs. placebo
3.4 mm Hg
Systolic Blood Pressure Reduction
Change in systolic blood pressure with liraglutide vs. placebo

Full Text

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Funding

Competing interests

Dr Blackman: consultant/advisory board participant for Novo Nordisk, Merck Canada, Valeant Canada, Paladin Labs Inc. Dr Foster: at the time of the study was a scientific advisory board participant for Con Agra Foods, United Health Group and Tate and Lyle, and a consultant to Eisai and Novo Nordisk; currently employed by Weight Watchers International. Dr Zammit: consultant for Acorda, Actelion, Alexza, Arena, Aventis, Biovail, Boehringer-Ingelheim, Cephalon, Elan, Eli Lilly, Evotec, Forest, Glaxo Smith Kline, Jazz, King Pharmaceuticals, Ligand, McNeil, Merck, Neurocrine Biosciences, Organon, Pfizer, Purdue, Renovis, Sanofi-Aventis, Select Comfort, Sepracor, Shire, Somnus, Takeda Pharmaceuticals, Vela, Wyeth; grants/research support from Abbott, Abbvie, Actelion, Ancile, Apnex, Arena, Astra-Zeneca, Aventis, Banyu, Biomarin, BMS, Catalyst, Cephalon Inc., CHDI, Elan, Epix, Eisai, Elminda, Evotec, Forest, Galderma, Genentech, Gilead, Glaxo Smith Kline, Gilead, H. Lundbeck A/S, Janssen, Johnson & Johnson, King, Merck and Co., National Institute of Health (NIH), Neurim, Neurocrine Biosciences, Naurex, Neurim, Neurogen, Novo Nordisk, Organon, Orphan Medical, Otsuka, Pfizer, Predix, Respironics, Saladax, Sanofi-Aventis, Sanofi-Synthelabo, Schering-Plough, Sepracor, Sunovion, Shire, Somaxon, Takeda Pharmaceuticals North America, Targacept, Teva, Thymon, Transcept, UCB Pharma, Ultragenyx, Predix, Vanda, Wyeth-Ayerst Research; honoraria received from Neurocrine Biosciences, King Pharmaceuticals, McNeil, Sanofi-Aventis, Sanofi-Synthelabo, Sepracor, Takeda Pharmaceuticals, Vela Pharmaceuticals, Wyeth-Ayerst Research; ownership interest in Clinilabs, Inc., Clinilabs IPA, Inc., Home Sleep and Respiratory Care, Nationwide Sleep Testing. Dr Rosenberg: received research grant support from Merck, Novo Nordisk, Pfizer, Teva, Jazz Pharmaceuticals, Sunovion Pharmaceuticals and Philips-Respironics. Dr Aronne: advisory board member for Myos Corporation; consultant, speaker, advisor, or received research support from Aspire Bariatrics Inc., Eisai, Ethicon Endo-Surgery Inc., GlaxoSmithKline Consumer Healthcare LP, GI Dynamics, Novo Nordisk, Pfizer, Takeda Pharmaceuticals, Vivus Inc., Zafgen Inc.; ownership interest in Myos Corporation and BMIQ. Dr Wadden: advisory board participant for Orexigen Pharmaceuticals, Inc., Novo Nordisk, Nutrisystem, and Shire Pharmaceuticals, with research support (to the University of Pennsylvania) from the first three companies. Dr Claudius: employee of Novo Nordisk and owns company stock. Dr Jensen: employee of Novo Nordisk and owns company stock. Dr Mignot: advisory board member, consultant for and research support from Jazz Pharmaceuticals; consultant for and research grant from Novo Nordisk; consultant for Reset Pharmaceuticals and Merck; expert witness for FTC.
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