Liraglutide for the Treatment of Weight Regain After Bariatric Surgery: A Systematic Review and Meta-analysis

Jul 10, 2024Obesity surgery

Liraglutide for Weight Regain After Weight-Loss Surgery: A Review and Combined Analysis

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Abstract

A statistically significant reduction in BMI of 8.56 kg/m was observed in patients using liraglutide after bariatric surgery.

The analysis included 16 studies with a total of 881 individuals, mostly female, aged 36 to 55 years, with a mean body mass index of 39.4 kg/m.
Patients had undergone bariatric surgery an average of 5 years prior to liraglutide treatment.
Over a follow-up period ranging from 3 months to 4 years, a mean reduction in total weight of 16.03 kg was noted.
65% of patients lost more than 5% of their total body weight, while 26% lost more than 10%.
The variability between studies is acknowledged as a limitation.

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INTRODUCTION: The efficacy of liraglutide for treating type 2 diabetes mellitus and obesity is well established, but their role in the treatment of weight regain after bariatric surgery remains unclear.

METHODS: We searched PubMed, Embase, and Cochrane Library databases in January 2024. A random-effects model was employed to compute mean differences (MD) and events per 100 observations with 95% confidence intervals (CI) for continuous and binary endpoints. Statistical analysis was performed using R software.

RESULTS: A total of 16 studies were included and 881 individuals. Patients were mostly female (50%), aged 36 to 55 years, with a mean body mass index (BMI) of 39.4 kg/m, and had BS surgery 5 years prior. Over a mean follow-up time ranging from 3 months to 4 years, it was observed a statistically significant reduction in BMI (MD - 8.56 kg/m; 95% CI 3.34 to 13.79; p < 0.01) and a mean reduction in total weight (MD - 16.03 kg; 95% CI 0.03 to 32.02; p = 0.05) after liraglutide use. Additionally, 65% of patients undertaking liraglutide showed total body weight loss (BWL) above 5% (65.8 events per 100 observations; 95% CI 54.96 to 75.20; p < 0.01), while 26% lost more than 10% of total BWL (26.77 events per 100 observations; 95% CI 19.17 to 36.02; p < 0.01). A limitation is a variability between the studies. 2 2

CONCLUSIONS: Our findings support the use of liraglutide for weight management in patients who experience weight regain after BS. Liraglutide is well tolerated and promotes significant weight loss, providing clinicians with a therapeutic option for this clinical challenge.

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Liraglutide for the Treatment of Weight Regain After Bariatric Surgery: A Systematic Review and Meta-analysis

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