Two-way communication between the liver, gut, and brain in fatty liver disease linked to metabolism: health impacts and future directions

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately one-third of adults worldwide.

• MASLD is increasingly recognized as a disorder that impacts multiple systems in the body.
• Patients with MASLD often experience fatigue, depression, anxiety, sleep disturbances, and cognitive complaints.
• The clinical symptoms reported by patients do not consistently correlate with liver tissue damage.
• Several mechanisms may interact to contribute to the symptoms experienced by those with MASLD.

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