What this is
- This study compares networks of loneliness, depressive symptoms, and anxiety symptoms in older adults before and during COVID-19.
- It utilizes to examine how these symptoms interact and change over time.
- Older adults (aged ≥ 60) at risk for depression were assessed using validated scales.
- The findings suggest that the pandemic altered the symptom networks, impacting mental health in older adults.
Essence
- The study found that during COVID-19, the networks of loneliness, depressive symptoms, and anxiety symptoms in older adults became more interconnected and complex compared to before the pandemic. Key symptoms like restlessness remained central in both periods.
Key takeaways
- The network during COVID-19 exhibited higher global strength, indicating that symptoms were more likely to influence each other. This suggests a more complex presentation of mental health issues among older adults during the pandemic.
- Feeling isolated from others had stronger connections with feelings of worthlessness and anticipatory anxiety during COVID-19 compared to before, highlighting how the pandemic exacerbated certain mental health challenges.
- Restlessness was the most central symptom in both networks, underscoring its importance in understanding and addressing mental health in older adults.
Caveats
- The study's cross-sectional design limits causal inferences about the relationships between symptoms. Longitudinal studies are needed for deeper insights.
- Variability in participant characteristics and the use of different measurement tools may affect the comparability of findings across timepoints.
Definitions
- Network analysis: A method used to study the relationships and interactions among symptoms in mental health, focusing on how symptoms influence each other.
AI simplified
Introduction
Despite COVID-19 no longer posing a global health emergency, it has adversely impacted people’s emotional well-being worldwide1. The pandemic hit older adults harder than the general population2. Before COVID-19, older adults were already facing multiple challenges, such as chronic illness, social isolation, bereavement, and barriers to accessing mental health services, including reduced mobility, lack of awareness, and stigma3. Therefore, common mental health problems, such as depression and anxiety, are common in older people, with depressive and anxiety symptoms being more prevalent than clinical syndromes. Systematic reviews suggested the prevalence of late-life depressive symptoms to be up to 28.4%4, and the prevalence of anxiety varying widely in the community (1.2–14%) and clinical (1–28%) settings for older people5. The pandemic has heightened feelings of isolation, fear of infection, and disruptions in routine healthcare services, further contributing to mental health challenges faced by older people6. These factors led to an increased prevalence of depressive and anxiety symptoms, especially among older persons with chronic illness during COVID-19, with 61% and 85% for depressive and anxiety symptoms, respectively7. Loneliness is another common issue experienced by older people, and the association between loneliness and mental health consequences has been consistently established8. For older people, the alteration of social networks, often due to retirement or the passing of a spouse, can increase loneliness and impact their quality of life and mental health8. Loneliness has been identified as both a risk factor for mental illness and as a mental health problem warranting attention9. A recent systematic review and meta-analysis during COVID-19 reported a pooled prevalence of loneliness as 28.6% (95% CI: 22.9–35.0%)10. During COVID-19, many disease mitigation measures, such as social distancing and lockdown, were reinforced to curb the spread of the virus and prevent at-risk groups from catching the virus. However, such measures escalated the feeling of loneliness in older adults, increasing the prevalence of mental health problems11,12. More targeted interventions are therefore needed to promote older persons’ mental health.
Network analysis has been utilized to understand mental health and psychiatric symptoms to develop more targeted interventions. In contrast to the traditional psychopathology theory derived from understanding physical disease, that is, the common cause theory of mental disorders13,14, the network approach to psychopathology perceives mental disorders as the result of a constellation of symptoms that interact with each other and, therefore, focuses on understanding symptom interactions15,16. In network analysis, each symptom is represented as a node, whereas the association between two nodes is shown as an edge. The importance of a symptom is reflected by centrality, and there are different types of centrality indices that indicate how a node exerts influence on the rest of the network17. Aliberti and Oliveira argue that the network approach has particular implications in advancing geriatrics or gerontology research, given that older adults’ health conditions often result from complex interactions between multimorbidity and geriatric syndromes18.
Mental disorders, especially common ones such as depression and anxiety, do not have conclusive and clear pathogenic pathways like physical diseases19. There is large symptom variability between individuals diagnosed with the same disorder20,21. Many factors, including age, gender and culture, may influence the presentation of symptoms22. Stressful events, interacting with the network but not included in it, may trigger specific symptoms and eventually spread through the whole network via the edges5, or make the symptoms more densely connected and have a higher chance of maintaining an “active state”23. COVID-19 was a collective stressful event, and understanding its impact on older people’s mental health from a network approach may deepen our knowledge of the effects of external factors on network structure and offer insight into targeted intervention design.
There has been a surge of studies into the mental health symptom networks during COVID-19. Several cross-sectional studies have been undertaken. For example, Cheung et al. found in the Hong Kong general population that guilt, sad mood, and energy symptoms were central in adults’ depression network during the COVID-19 pandemic24. In another study, Jin et al. identified sad mood, guilt, motor problems, and lack of energy as central symptoms in older adults’ networks in Hong Kong25. In a sample of older Chinese with disabilities, researchers found that felt sadness, uncontrollable worry, and trouble relaxing were the most central symptoms in the anxiety-depression network, which may be potential targets for intervention26. Hoffart et al. examined the networks of pandemic-related states (that is, loneliness, fear of infection, and financial worry), depression, and anxiety among adults in Norway27. They found that different pandemic-related states were associated with different anxiety and depression symptoms, and loneliness was specifically associated with various depression symptoms during the COVID-19 lockdown27. However, in another study examining the networks of loneliness, anxiety, and depression, Owczarek et al. found that loneliness was more distinct from anxiety and depression symptoms as reflected by low bridge expected influence (BEI) during the first lockdown in the UK28. In network theory, BEI expresses a node’s connectivity with the other network29. When applied to the understanding of symptom networks, the higher the BEI, the greater the connection between a symptom of one network (e.g., depressive symptom) with the symptom of the other network (e.g., somatic symptom clusters). Targeting central and high BEI symptoms may have ripple effects that deactivate the symptom network and, therefore, be more cost-effective.
The variations in research populations, measurement, and statistical analysis may lead to differences in study findings. Nevertheless, these studies have deepened our understanding of symptom-level interactions and may offer insights for designing targeted interventions. However, most existing studies are based on cross-sectional design; more longitudinal studies are needed to draw causal links and implement more targeted intervention strategies at different pandemic stages28,30.
To date, research examining the symptom networks of loneliness, anxiety, and depression among older adults remains scarce. In addition, limited studies have compared the symptom networks in older adults before and during the pandemic. Yu and Mahendran found that the associations between social isolation and affective symptoms were strengthened among older adults during the COVID-19 lockdown in Singapore30. However, global strength, in other words, overall network connectivity, did not significantly differ when pre-pandemic and lockdown comparisons were made30. Ramos-Vera et al. found that depressive symptoms and loneliness reinforced the experience of nervousness in older adults over two pandemic waves31, but this study could not make comparisons with pre-pandemic networks. Odenthal et al. utilized longitudinal data to examine the consistency of the network between loneliness and mental health symptoms before COVID-19 and the third incidence peak in the UK32. Their research suggests that the symptom networks were consistent across time, and loneliness and self-worth were identified as key symptoms to target for distress in older adults aged 50 years and over32. Apart from this study, however, no other study has compared the loneliness, anxiety, and depressive symptoms network in older people before and after the pandemic started, especially among at-risk groups. All in all, it remains unclear whether and how the symptom networks in older adults with mental health risks change in the presence of COVID-19 stressors.
Given the research gaps, this study aimed to: (1) investigate the networks of loneliness, depressive symptoms, and anxiety symptoms in community-dwelling older Chinese at risk of mental health problems before COVID-19, (2) during COVID-19, and (3) compare the two networks at different timepoints by propensity score matching (PSM). Several studies have used PSM previously to reduce the imbalance between cross-sectional populations recruited at different times and compared networks between them33,34. In the absence of longitudinal data, PSM may be a viable option to estimate the causal effects35. Understanding the interactions between symptoms of common mental health problems may aid professionals and policymakers in formulating cost-effective strategies to support the well-being of the ageing population.
Methods
Study setting and participants
This cross-sectional comparative study was conducted between October 2016 and December 2022 in Hong Kong. Data were retrieved from the baseline assessment of participants enrolled in the JoyAge project (“Jockey Club Holistic Support Project for Elderly Mental Wellness”) in Hong Kong from 2016 to 2019 (Phase I: pre-COVID-19) and 2020 to 2023 (Phase II: during COVID-19) (ClinicalTrials.gov NCT03593889↗ and NCT04863300↗, respectively)36. The university research team partnered with community aged care and mental health care service units, all of which were non-governmental organizations (NGOs), to provide standardized JoyAge services to community-dwelling older Chinese at risk of depression or with depressive symptoms. The JoyAge service incorporates collaborative stepped-care and peer support services and is delivered by trained social workers and peer supporters. Details of the service model, project implementation, and study protocol can be found in the published protocol and project website36.
All participants were recruited through JoyAge partner NGOs. Inclusion criteria were: (1) aged 60 or above; (2) having mild depressive symptoms or above (PHQ9 total scores > 4); (3) being able to provide informed consent to participate. Exclusion criteria were: (1) known history of autism, intellectual disability, schizophrenia-spectrum disorder, bipolar disorder, Parkinson’s disease, or dementia; and (2) (temporary exclusion criteria) imminent suicidal risk. We used the age of 60 as the cutoff, because in a report to the World Health Organization, the authors stated that there was no United Nations (UN) standard numerical criterion, but the UN agreed that the cutoff should be 60+ years to refer to the older population37. In addition, for statistical and public administrative purposes, many countries and regions, including Hong Kong, also set age 60 as eligible for citizens to receive certain benefits and welfare38.
Hong Kong experienced various community outbreaks of COVID-19 from early 2020 to 2023. In the first year of the COVID-19 outbreak, Hong Kong, a city with high mobility and population density, maintained a relatively low number of infections compared with nearby cities. Based on the experience of SARS in 2003, the community complied with the imposed restrictions set by the government and demonstrated good awareness in terms of maintaining personal hygiene and self-isolation. Examples of imposed restrictions included compulsory quarantine, suspended flights, mandatory confinement following positive testing, and curtailed hours to access community facilities39. However, while most countries started to resume social and economic activities in 2021 by “living with COVID”, a “dynamic COVID-zero” strategy was maintained in Hong Kong through strict social distancing and compulsory quarantine measures39. Although this approach appeared effective in the first two years, Hong Kong experienced an unexpected surge in COVID-19 cases during the emergence of the Omicron variant in early 202240. The study was reviewed and approved by the Human Research Ethics Committee (HREC) of the University of Hong Kong, and all respondents gave written consent to participate in this study. The study procedures have been performed in accordance with the Declaration of Helsinki.
Measurements
Loneliness
The Three-Item Loneliness Scale (UCLA-3) is adapted from the Revised UCLA Loneliness Scale to assess the subjective feeling of loneliness through three questions asking how often a person feels (i) lack of companionship, (ii) left out, and (iii) isolated41. A validated Chinese version was used with a 4-point Likert scale scoring from 0 (not at all) to 3 (nearly every day), giving a total score ranging between 0 and 942. The internal consistency obtained by the scale was good (Cronbach’s α = 0.82) in this sample.
Depressive symptoms
Depressive symptoms were measured by the validated Chinese version of the Patient Health Questionnaire-9 item (PHQ-9) for older people43. It is a 9-item instrument that assesses the frequency of the main depressive symptoms during the past two weeks. Items are rated on a 4-point Likert scale ranging from 0 (not at all) to 3 (nearly every day). The total score can range from 0 to 27, with higher scores reflecting more severe depressive symptoms. Scores of 5–9, 10–14, 15–19, and 20 and above represent mild, moderate, moderately severe, and severe depressive symptom levels, respectively. The internal consistency of the Chinese version of PHQ-9 was acceptable in the current study (Cronbach's α = 0.62).
Anxiety symptoms
Anxiety symptoms were measured using the Generalized Anxiety Disorder 7-item scale (GAD-7)44. Responses to each anxiety symptom are rated on a 4-point Likert scale of its frequency of occurrence from 0 (not at all) to 3 (nearly every day), with total scores ranging from 0 to 21 and higher scores reflecting more severe anxiety symptoms. The internal consistency of the Chinese version of GAD-7 in this study was good (Cronbach's α = 0.88).
Covariates
The following covariates were measured: age (years), gender (male vs female), education level (no formal education, primary, secondary, associate and above), mobility (walking without help, walking with a stick, needing other help to move), low income (recipient of government subsidy vs non-recipient), living arrangements (living alone vs living with other(s)), and marital status (single, married/cohabiting, widowed, separated/divorced).
Data analyses
All analyses used R (version 4.2.3).
Propensity score matching model
A propensity score model was developed to increase the balance between the pre-COVID-19 and the COVID-19 groups. Given the shortcomings of the linear model, particularly with skewed data, the propensity score was estimated using a probit regression35. The R package MatchIt was used for the analysis45, and all covariates were used for the matching.
Network estimation
Following previous studies, we checked the informativeness (standard deviation of the item) and redundancy (< 25% of significantly different correlations) of the items using functions from R packages compareGroups and networktools, respectively46,47. In the study’s network structure, each node represents one unique item from the PHQ-9, GAD-7, and UCLA-3 measures. The connections, namely, edges, between nodes represent the partial correlation between the two nodes, and the strength of edges is referred to as weight. The Gaussian Graphical Model (GGM) was applied to estimate the network based on partial correlation coefficients48. The GGM was regularized by the graphical Lasso based on an extended Bayesian information criterion (EBICglasso) with a tuning parameter (default: γ = 0.5)48. The purpose was to reduce false positives and to build a more parsimonious model.
Centrality
Central symptoms were identified via expected influence (EI), which is the summed weight of all edges extending from a given node49. Three other major centrality indices, namely, Betweenness, Closeness, and Strength, were also computed to examine which symptoms were most important in the loneliness–depression–anxiety symptoms network50,51. Strength is the absolute sum of edge weights connected to a node, Betweenness refers to the frequency of a node lying on all the shortest paths between other nodes, while Closeness is calculated as the inverse of the sum of the distance from a node to all other nodes in the network16. Betweenness and closeness have demonstrated poor reliability in psychopathology network studies48. Compared to strength, EI has been suggested to be more reliable as it considers both positive and negative edges48. Therefore, we reported EI centrality in the main analysis and all other centrality measures in the supplementary materials. The R packages networktools and qgraph were used to perform the analyses47,52.
Network accuracy and stability
We followed previous studies and examined the accuracy and stability of the network models. First, we used non-parametric bootstrapping to bootstrap the 95% confidence intervals (CI) of the edge weights, providing an estimate of the accuracy of edges in the networks, with narrower CIs indicating a more trustworthy network48,53. Second, we used the correlation stability coefficient (CS-C) to assess the stability of the centrality indices subset bootstrap, that is, by dropping participants and re-estimating the network54. CS-C represented the maximum proportion of cases that can be dropped (with 95% probability) to maintain a correlation larger than 0.7 with the original centrality value. Thresholds of 0.25 suggest modest stability, and 0.5 suggest strong/high metric stability48. The stability of EI was reported in the main analysis, and stability of other centrality measures, including Betweenness, Closeness, and Strength, were reported in Supplementary materials. The R package bootnet was used to perform the analyses49.
Association between symptom severity, variability, and centrality index
We calculated the associations between the centrality index (EI) and the mean score of PHQ-9, GAD-7, and UCLA-3 items using Spearman’s rank-order correlation to test whether the most central symptoms were the most severe ones55. We also calculated the association between the centrality index and standard deviation for all the items with Spearman’s rank-order to test whether symptom centrality could be attributed to the items’ differential variability55.
Comparison of network characteristics by time
Adapted from previous studies, differences between the networks of the two timepoints were assessed using the Network Comparison Test (NCT) in the R package NetworkComparisonTest (version 2.2.1)56. This test uses 1000 permutations to compare the global network strengths (absolute sum of all edge weights) and network structures (edge weight distributions) between the two networks. Finally, the differences in strength for each edge connecting two nodes were compared between the two networks after controlling for multiple tests (Holm–Bonferroni correction of p values).
Results
Participants’ characteristics before and after matching
All individual items were above the informativeness threshold (that is ± 2.5 SD below the mean level), and no item was considered statistically redundant in the loneliness–depression–anxiety symptoms network before COVID-19. GAD-7 items (hereafter A) A1 (feeling nervous) and A7 (feeling afraid as if something awful might happen) had less than 25% of significantly different correlations from others. However, we included all clinical measure items to keep the two network nodes consistent. Supplementary Table 2 summarizes all individual items and comparisons between the two times. Participants during COVID-19 reported higher mean severity ratings in all items than pre-COVID-19 participants.
() Loneliness–depression–anxiety symptoms network before COVID-19 (N = 2549). Green circles represent loneliness items, yellow depressive symptoms, and blue anxiety symptoms. Solid edges represent positive edge weights (a positive relationship between symptoms), dashed edges represent negative edge weights (a negative relationship between symptoms), and the thickness of the edges represents the strength of associations between nodes. () Standardized centrality indices (Expected Influence) of the network structure of loneliness–depression–anxiety symptoms (scores). a b Z
| Mean (SD)/N (%) | Before matching | After matching | ||||
|---|---|---|---|---|---|---|
| Pre-COVID-19 (N = 3150 with missing) | During COVID-19 (N = 4514 with missing) | p | Pre-COVID-19 (N = 2549) | During COVID-19 (N = 3506) | p | |
| Age, years | 75.61 (10.57) | 73.53 (8.00) | < 0.001 | 73.57 (8.41) | 73.69 (8.00) | 0.07 |
| Gender, female | 2229 (77.7%) | 3753 (83.6%) | < 0.001 | 1988 (78.0%) | 2805 (80.0%) | 0.06 |
| Education level | < 0.001 | < 0.001 | ||||
| No formal education | 1003 (34.5%) | 772 (17.2%) | 876 (34.4%) | 602 (17.2%) | ||
| Primary school | 1099 (37.8%) | 1850 (41.0%) | 947 (37.2%) | 1445 (41.2%) | ||
| Secondary school | 707 (24.2%) | 1594 (35.3%) | 639 (25.1%) | 1236 (35.3%) | ||
| Associate degree and above | 102 (3.5%) | 287 (6.4%) | 87 (3.4%) | 223 (6.3%) | ||
| Mobility | < 0.05 | 0.18 | ||||
| Able to walk without any help | 1801 (61.8%) | 3250 (74.6%) | 1565 (61.4%) | 2233 (63.7%) | ||
| Able to walk with stick | 972 (33.4%) | 985 (22.6%) | 861 (33.8%) | 1174 (33.5%) | ||
| Reliant on other help for mobility | 139 (4.8%) | 122 (2.8%) | 123 (4.8%) | 99 (2.8%) | ||
| Low-income, recipient of government subsidy | 938 (31.2%) | 853 (19.0%) | < 0.001 | 762 (29.9%) | 765 (21.8%) | < 0.001 |
| Living status, living alone | 1247 (41.5%) | 1790 (39.9%) | 0.17 | 1034 (40.6%) | 1430 (40.8%) | 0.26 |
| Marital status | 0.19 | 0.39 | ||||
| Single | 176 (5.8%) | 303 (6.7%) | 155 (6.1%) | 246 (7.0%) | ||
| Married/cohabiting | 1167 (39.6%) | 1778 (41.2%) | 1037 (40.4%) | 1338 (38.1%) | ||
| Widowed | 1311 (44.5%) | 1612 (37.3%) | 1120 (43.9%) | 1477 (42.1%) | ||
| Separated/divorced | 292 (10%) | 627 (14.5%) | 237 (9.3%) | 445 (12.7%) | ||
| Mental health measures | ||||||
| Depression, PHQ-9 total scores | 8.43 (3.52) | 9.98 (3.73) | < 0.001 | 8.17 (3.28) | 10.31 (3.74) | < 0.001 |
| Anxiety, GAD-7 total scores | 5.64 (4.67) | 7.14 (4.6) | < 0.001 | 5.59 (4.62) | 7.61 (4.67) | < 0.001 |
| Loneliness, UCLA-3 total scores | 4.57 (2.9) | 4.92 (2.27) | < 0.001 | 4.53 (2.89) | 4.90 (2.28) | < 0.001 |
Model 1: Loneliness–depression–anxiety symptoms network before COVID-19
These results are interesting because in terms of severity rating (that is, frequency of experiencing the symptoms, synchronized in three scales), participants scored highest in L3 (feeling isolated from others; mean = 1.69, SD = 1.10) and D3 (sleep problems; mean = 1.68, SD = 0.97); while A5 received an average rating of 0.69 (SD = 0.82), and all GAD-7 items had an average score lower than 1 (mean = 0.80, SD = 0.85), indicating those symptoms were experienced less frequently than several days in the previous two weeks. In terms of cross-scale connection, L3 had the strongest connection with D9 (suicidal ideation; part r = 0.08), which warrants attention for more targeted intervention because of the high risk indicated by D9. However, despite high mean severity, D3 (sleep problems) had a very weak EI on other mental health symptoms except for D4 (fatigue), another somatic symptom commonly reported by older people. Bivariate analysis between symptom severity (mean score) and EI revealed that they were not related (rs = − 0.23, p = 0.34), symptom severity variance (standard deviation) was not correlated with EI either (rs = − 0.05, p = 0.83), suggesting that symptom centrality was not related to its severity level and variability.
Regarding network stability, the case-dropping procedure showed that the EI (CS-C = 0.75) value remained stable after dropping different proportions of the sample; the EI value was the same for Strength (CS-C = 0.75), and Closeness (CS-C = 0.75), and modest for Betweenness (CS-C = 0.44) (Supplementary Fig.b). The edge weight bootstrapped difference test revealed that many comparisons among edge weights were statistically significant (Supplementary Fig.a), and there was substantial overlap among the 95% CIs of edge weights (Supplementary Fig.b). 2 3 3
Bootstrapped difference tests between node expected influence in the pre-COVID-19 network. Gray boxes indicate nodes that do not significantly differ from one another. Black boxes represent nodes that differ significantly from one another (α = 0.05). White boxes show the values of node expected influence.
Model 2: Loneliness–depression–anxiety symptoms network during COVID-19
These results found in Model 2 (during COVID-19) are largely similar to those in Model 1 (pre-COVID-19). Anxiety symptoms had the highest centrality despite a low severity rating (mean A5 = 1.03, SD = 0.84; mean A2 = 1.17, SD = 0.87). In terms of cross-scale connection, L3 consistently has the strongest connection with D9 (suicidal ideation; part r = 0.09); at the same time, L3 also received a high severity rating (mean = 1.78, SD = 0.90), which is alarming and suggests that feeling of isolation deserves more attention. Similarly, despite high mean severity, D3 (sleep problems, mean = 1.82, SD = 0.92) had weak connections with other mental health symptoms. In the COVID-19 network, D2 (depressed mood) took up a more central role and had a high connection with D9 (suicidal ideation; part r = 0.13) than in the pre-COVID-19 network. Bivariate analysis between symptom severity (mean score) and EI revealed that they were not related (rs = − 0.35, p = 0.41), symptom severity variance (standard deviation) was not correlated with strength either (rs = − 0.38, p = 0.61), suggesting that symptom centrality was not related to its severity level and variability.
Regarding network stability, the case-dropping procedure showed that the EI (CS-C = 0.75) value remained stable after dropping different proportions of the sample. The EI value was the same for Strength (CS-C = 0.75), Closeness (CS-C = 0.75), but low for Betweenness (CS-C = 0.13) (Supplementary Fig.b). The edge weight bootstrapped difference test revealed that many comparisons among edge weights were statistically significant (Supplementary Fig.a), and there was substantial overlap among the 95% CIs of edge weights (Supplementary Fig.b). 4 5 5
() Loneliness–depression–anxiety symptoms network during COVID-19 (N = 3506). Green circles represent loneliness items, yellow depressive symptoms, and blue anxiety symptoms. Solid edges represent positive edge weights (a positive relationship between symptoms), dashed edges represent negative edge weights (a negative relationship between symptoms), and the thickness of the edges represents the strength of associations between nodes. () Standardized centrality indices (Expected Influence) of the network structure of loneliness–depression–anxiety symptoms (scores). a b Z
Bootstrapped difference tests between nodes expected influence in the network during COVID-19. Gray boxes indicate nodes that do not significantly differ from one another. Black boxes represent nodes that differ significantly from one another (α = 0.05). White boxes show the values of node expected influence.
Network comparisons between the two timepoints
Out of 171 edges between 19 symptoms, 19 edges had significant differences between the two networks, as summarized in Supplementary Table 4 (p < 0.05 after Holm–Bonferroni corrections). Among the 19 significantly different edges, 13 were within the same scales (nine depression, three anxiety, one loneliness), and six were across scales (three between anxiety and depression, two between depression and loneliness, and one between anxiety and loneliness). In general, depressive symptoms were more strongly coupled during COVID-19. One notable change was a stronger connection between L3 (feeling isolated from others) and D6 (worthlessness or guilt) and between L3 and A7 (feeling afraid as if something awful might happen), suggesting that during COVID-19, feeling isolated from others, possibly induced by disease mitigation measures, had a higher probability of co-occurring with feeling worthless or guilty, and being afraid that something awful might happen.
Comparison of network centrality indices between respondents recruited before and during COVID-19.Anxiety symptoms, items from the Generalized Anxiety Disorder-7 item scale,Depression symptoms, items from the Patient Health Questionnaire-9 item scale,Loneliness, items from the UCLA-3 item loneliness scale. *< 0.05. A D L p
Discussion
This study had three aims: (1) to investigate the networks of loneliness, depression, and anxiety symptoms in community-dwelling older Chinese at risk of mental health problems before and (2) after COVID-19, and (3) to compare the two networks. To our knowledge, this is the first study to characterize the networks of the aforementioned common mental health problems in older Chinese and compare the pre-COVID-19 and COVID-19 networks using a propensity score matching approach. Loneliness, depressive symptoms, and anxiety symptoms are common in older people, and a deeper understanding of the symptom structures may inform mental health professionals in developing more targeted interventions. In addition, some of the findings may be relevant for policymakers in balancing disease mitigation measures and older people’s mental health needs in future public health crises.
First, we found that in the loneliness–depression–anxiety symptoms network in community-dwelling older people at risk of depression, A5 (being restless) was the most central symptom. It is arguably an anxiety symptom that has some conceptual overlap with depression, and it was most central in both networks regardless of time, suggesting a relatively robust central role. Its centrality was not associated with symptom severity or symptom variability. In terms of symptom severity, this community sample reported a higher frequency of experiencing loneliness, followed by depressive symptoms, but least frequent anxiety. This disassociation between symptom severity and centrality was consistent with findings from previous studies. For example, Fried demonstrated that insomnia exerted a considerable influence on other symptoms and had higher centrality despite comparatively lesser severity within the context of major depressive disorder (MDD)20. Beard reported in a network analysis of depression and anxiety symptoms in a psychiatric sample that symptoms like feeling afraid that something awful might happen and feeling easily annoyed or irritated were the most central but not always the most severe57. These findings suggest that the most central symptoms in a network might not necessarily be the most severe, but they could play a significant role due to their diverse or strong connections with other symptoms, therefore, effectively activating the problematic network. These central but less severe symptoms might be easily overlooked in the traditional psychopathology framework, especially if professionals simply use sum scores to differentiate mental health needs. More research is needed to gain a clearer understanding of symptom networks and disassociation between centrality and severity.
Second, being restless and feeling isolated from others in older adults need more attention. Research has shown that older adults can experience anxiety symptoms somewhat differently from younger people. For instance, some older adults might display more physical symptoms of anxiety, such as restlessness or an inability to relax, rather than cognitive symptoms often associated with anxiety, like pervasive worry58. Even if restlessness receives a high severity rating in older adults, it could be attributed to other comorbidities like chronic pain and overlooked as a mental health symptom59. Hence, the presence or absence of symptoms such as restlessness could help discern the level of anxiety in older adults. Our findings augment the literature by suggesting its central role in driving the loneliness–depression–anxiety symptoms network in community-dwelling older adults. Although not among the most central symptoms in this study, feeling isolated from others had significant connections with suicidal ideation in networks other than the depressive symptom network. During COVID-19, older people experienced elevated social isolation and loneliness, which may be attributed to disease mitigation measures such as social distancing60. Some studies argue that loneliness, but not social distancing, was associated with suicidal ideation during the COVID-19 pandemic61. Researchers have suggested promoting social connection as public health messaging, mobilizing diverse social support networks, including the family and community, and developing technology-based interventions to increase accessibility to reduce loneliness60. Our findings also support interventions targeting loneliness, which could have a ripple effect on reduced suicidal risk. For example, community aged care services can include screening for loneliness using the UCLA-3item scale. For those who screened positive, particularly on the third item, feeling isolated from others, targeted interventions to reappraisal the loneliness and self-harm thoughts using cognitive behavioral therapy (CBT), to increase social engagement and peer support such as community activities and volunteer opportunities, or to increase access to services such as telehealth during times of public health crisis may be offered to older people62–64.
Third, compared to the pre-COVID-19 network, the loneliness–depression–anxiety symptoms network during COVID-19 had significantly larger global strength and distribution of edge weights, which may reflect the influence of the pandemic on wider symptom activation and more complex presentation of symptom associations. The higher global strength of the network suggests that symptoms may have a greater impact on each other, and older people may experience more persistent symptoms during COVID-19, as the activation of one symptom could lead to a higher likelihood of symptoms reinforcing one another. This finding differs from that of Yu and Mahendran, who reported no significant difference in the global strength of pre-COVID-19 and lockdown networks despite finding altered dynamics between symptoms brought by lockdown30. Their study collected data from mainly healthy community-dwelling older people with a pre-COVID-19 mean score on the Geriatric Depression Scale (GDS) of 1.02 and a lockdown GDS mean score of 2.11, indicating no depression risk30. In contrast, our sample comprised those at risk of depression, with a mean PHQ-9 score exceeding 4. We speculate that the variation in results could be attributed to having different respondent characteristics. It is plausible that those without mental health risks pre-COVID-19 may have higher resilience and buffer when facing stressful events like lockdown, while changes in the external environment are more likely to cause “cascading failure” among those already at-risk65. Our findings may echo previous research in drawing attention to those with pre-existing mental health conditions66, adding evidence from a network perspective of psychopathology.
Four, compared to the pre-COVID-19 network, the depressive symptoms (D2—depressed mood, D4—fatigue, and D7—concentration problem) showed higher centrality, and two edges connecting symptoms from different scales, L3 (feeling isolated from others) and D6 (feelings of worthlessness or guilt), and L3 and A7 (feeling afraid as if something awful might happen) became stronger during COVID-19. We did not specify domains of symptoms in the network analysis (different initials just for naming the variables). Also, we did not examine the bridge expected influence because, conceptually, some depression and anxiety symptoms may overlap, as in the case of depression and loneliness. Nevertheless, the results showed that feeling isolated from others was more likely to couple with feelings of worthlessness or guilt, a significant depressive symptom found to be associated with the presence of psychotic features and relapse of depression67,68, and more likely to co-occur with feeling afraid as if something awful might happen, a symptom that indicates anticipatory anxiety and has a strong connection with other anxiety symptoms within the network69. These findings emphasize the importance of targeting loneliness to reduce coactivation between symptoms. Finally, compared to pre-COVID-19, all loneliness, depression, and anxiety symptoms received higher severity ratings. Despite not being a longitudinal study, through PSM, the two samples were largely matched, and the elevated mental health risks are consistent with other studies2.
This study had several strengths. First, it used a network approach to examine common mental health symptoms, which can capture the complexity, interconnectedness, and dynamic nature of mental health networks. With more conventional research methods, the focus would be on more severe symptoms and less on the function of individual symptoms in maintaining the whole network or linking to other symptom clusters. Second, data from this study were collected from community-dwelling older people at risk of depression, who were rated not only on depressive symptoms but also anxiety and loneliness, two other common comorbid mental health problems in old age. Given that comorbidity is more common than not, this sample provides a more realistic depiction of mental health challenges experienced by community-dwelling older people than other studies focusing on one or two conditions. Third, this study used PSM to minimize the imbalance between participants recruited before and during the COVID-19 community breakout and offered a different perspective on examining the mental health impact of the pandemic, in other words, the changes in symptom network structure. Finally, data from this study were retrieved from an ongoing large-scale service project; participants may not typically participate in research or were previously unknown to mental health services. Therefore, the study’s results may have direct service implications for mental health providers to design targeted interventions and examine their impact on the symptom network structure through longitudinal studies.
Several limitations need to be considered in interpreting the results of this study. First, the edges in each network were calculated with cross-sectional data, precluding estimations of important network characteristics such as the direction of edges. Although PSM may offer some insight into COVID-19’s influence on the network, the data were nevertheless retrieved from different individuals. Experimental or prospective designs are required to test the assumptions underlying causality57. Second, although the qgraph glasso and EBIC procedure conducts model comparison that maximizes fit, there are no clear best good-of-fit metrics for network comparison tests70. Third, although all items were from standardized measurements, some items may have conceptual overlaps (for example, A2 cannot stop/control worrying, and A3 worrying too much about different things) that are especially harder for community-dwelling older people to differentiate, and potentially artificially inflating edge weights and centrality, in particular among anxiety symptoms.
In summary, the results of the study reveal the importance of a specific anxiety symptom, restlessness, and loneliness item, feeling isolated from others, in the network of loneliness–depression–anxiety symptoms among community-dwelling older people at risk of depression, and their centrality was disassociated from symptom severity or variability. Comparing networks at two timepoints, we found that the network during COVID-19 had larger global strength and edge variability, suggesting wider symptom activation and more complex presentation of symptom associations. In particular, depressed mood became more important in connecting with other symptoms in the network, and feeling isolated from others was more likely to co-occur with important depression and anxiety symptoms associated with higher relapse of depression and anticipatory anxiety. These findings may assist mental health service providers to make more personalized interventions for older people and inform policymakers to balance disease mitigation measures and people’s mental health needs.
Supplementary Information
Supplementary Information.