Long non-coding RNAs and therapeutic resistance in multiple myeloma: from molecular insights to clinical applications

Jan 17, 2026Clinical and experimental medicine

Long non-coding RNAs linked to treatment resistance in multiple myeloma, from molecular details to clinical use

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Abstract

(lncRNAs) may play significant roles in the biology of multiple myeloma (MM).

lncRNAs are implicated in key molecular processes such as regulating gene expression and influencing disease progression in MM.
These RNA molecules may affect treatment response by interacting with cellular signaling pathways like PI3K/Akt and STAT3.
Emerging treatment strategies targeting lncRNAs include RNA-based therapeutics and CRISPR/Cas9 technology.
The potential of lncRNAs as biomarkers and therapeutic targets in MM is highlighted, suggesting avenues for future research.

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Multiple myeloma (MM) is a complex hematologic malignancy characterized by the abnormal proliferation of plasma cells in the bone marrow. Despite advances in therapy, resistance remains a significant obstacle to curing the disease. (lncRNAs), a broad family of regulatory RNA molecules, have recently been recognized as important players in MM biology, influencing disease progression and treatment response. This review explores current insights into the diverse roles of lncRNAs in MM, focusing on their involvement in key molecular processes, including miRNA sponging, epigenetic regulation, apoptosis, and interactions with signaling pathways such as PI3K/Akt and STAT3. Additionally, the review evaluates emerging treatment strategies targeting lncRNAs, including RNA-based therapeutics, CRISPR/Cas9 technology, and exosome-mediated delivery systems, assessing their potential to overcome drug resistance and improve clinical outcomes. By integrating molecular research with clinical implications, this review emphasizes the promise of lncRNAs as biomarkers and therapeutic targets in MM and offers a framework for future research and development.

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Long non-coding RNAs and therapeutic resistance in multiple myeloma: from molecular insights to clinical applications

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