Expression and prognostic significance of long noncoding RNA AK001796 in esophageal squamous cell carcinoma.

Jan 19, 2019European review for medical and pharmacological sciences

Levels and Predictive Value of Long Noncoding RNA AK001796 in Esophageal Squamous Cell Cancer

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Abstract

AK001796 was found to be elevated in human esophageal squamous cell carcinoma (ESCC) samples compared with adjacent normal tissues (p<0.01).

High levels of AK001796 expression are significantly associated with lymph node metastasis (p=0.032).
Increased AK001796 expression correlates with advanced UICC stage (p=0.016).
Patients with high AK001796 levels experience significantly lower overall survival (OS) (p=0.010).
Higher AK001796 expression is associated with reduced disease-free survival (DFS) (p=0.001).
AK001796 is identified as an independent poor prognostic factor for both OS and DFS in ESCC patients.

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OBJECTIVE: Previous study has reported that long noncoding RNA AK001796 (AK001796) functions as a tumor promoter in esophageal squamous cell carcinoma (ESCC). However, its clinical in ESCC patients remains largely unclear. The purpose of the present study was to evaluate the prognostic value of AK001796 in ESCC patients.

PATIENTS AND METHODS: The expression levels of AK001796 in ESCC tissues and matched normal tissues were detected by RT-PCR. Association between AK001796 levels and clinicopathological factors was also analyzed by chi-square test. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method and log-rank test. The predictors for OS and DFS were assessed by univariate analysis and multivariate analysis using Cox's proportional hazards model.

RESULTS: We found that AK001796 was elevated in human ESCC samples compared with the adjacent normal tissues (p<0.01), and the high level of AK001796 expression was significantly correlated with lymph node metastasis (p=0.032) and advanced UICC stage (p=0.016). Interestingly, Kaplan-Meier analysis indicated that patients with high AK001796 expression had a significantly lower OS (p=0.010) and DFS (p=0.001). Moreover, we showed that AK001796 was an independent poor prognostic factor for OS and DFS in ESCC patients through univariate and multivariate analysis.

CONCLUSIONS: Our data provide important evidence that AK001796 may be a useful biomarker of advanced progression and poor prognosis of ESCC.

Expression and prognostic significance of long noncoding RNA AK001796 in esophageal squamous cell carcinoma.

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