Psychopharmacology

Long-term low-dose psilocybin causes gene regulation changes in the thinking areas of rat brains

Updated

Abstract

Psilocybin microdosing may influence molecular mechanisms related to affective and anxiety disorders.

  • Repeated administration of sub-perceptual doses is referred to as microdosing.
  • The medial prefrontal cortex (mPFC) is a key area of interest for understanding these effects.
  • Epigenetic regulation in the mPFC is suggested to play a role in the therapeutic potential of psilocybin.
  • Current knowledge on the molecular mechanisms involved remains limited.

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