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The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
Longer life from lower IGF-1 signals may depend on how stable mitochondrial DNA is
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Abstract
Reduced insulin-like growth factor-1 (IGF-1) signaling does not extend the life span of mitochondrial mutator mice.
- Suppression of IGF-1 signaling typically promotes longevity and protects against age-related diseases.
- In mitochondrial mutator mice, the usual longevity effects associated with IGF-1 suppression were either blocked or blunted.
- The findings indicate that the beneficial effects of IGF-1 suppression may depend on the health of the mitochondrial genome.
- This research highlights a potential hierarchy in the biological pathways that influence aging in mammals.
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