Loss of daily phase relations identified by multiomic analyses in acute pancreatitis

Mar 12, 2026Biochemistry and biophysics reports

Disrupted daily biological rhythms found in acute pancreatitis through multiple molecular analyses

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A potential association between circadian rhythm dysregulation and disease severity in acute pancreatitis was identified.

Altered rhythmic expression of circadian genes may occur in patients with acute pancreatitis.
Specific metabolites linked to circadian rhythms could be modified in the context of the disease.
Findings suggest that circadian rhythms may play a role in the severity of acute pancreatitis.
The study integrates multiomics data from peripheral whole blood samples of acute pancreatitis patients.

AI simplified

Acute pancreatitis (AP) is sudden inflammation of the pancreas which can cause organ failure and death, and with no targeted therapies in the clinic, there is an imperative to identify new potential avenues for therapeutics discovery. This exploratory study investigates the potential role of circadian rhythms in AP pathogenesis. We integrated and analysed multiomics data, including transcriptomics, metabolomics, and clinical laboratory measurements, synthesised from peripheral whole blood samples obtained from AP patients. Our exploratory findings identified a potential association between circadian rhythm dysregulation and disease severity. Specifically, we observed that the rhythmic expression of circadian genes across a 24-h period, such as the circadian locomotor output cycles kaput () and the brain and muscle ARNT-Like 1 () gene, and a specific subset of metabolites may be altered in AP. These exploratory results provide a foundation for future investigations into the potential therapeutic implications of targeting circadian rhythms in AP. Additional studies are required to validate these findings and to elucidate the specific mechanisms involved. CLOCK BMAL1

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (XML) ↗View full text ↗

Loss of daily phase relations identified by multiomic analyses in acute pancreatitis

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief