Journal of affective disorders

Low-dose ketamine may change brain signal complexity in hard-to-treat depression

Updated

Abstract

Entropy reductions in brain regions linked to emotional regulation were observed in patients with major depressive disorder.

  • Patients with major depressive disorder show reduced entropy in brain areas involved in regulating emotions and motivation.
  • The effect of low-dose ketamine on these entropy reductions is not yet established.
  • Further investigation is needed to determine if ketamine can alter these brain activity patterns.

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