Frontiers in immunology

The lung-gut-brain connection in non-small-cell lung cancer involving three key signaling pathways

Updated

Abstract

The gut-lung axis is associated with immunotherapy responses in non-small-cell lung cancer (NSCLC).

  • The relationship between gut microbiota and lung health involves long-range communication.
  • Current reviews primarily emphasize chemical signaling of microbial metabolites.
  • The roles of enteroendocrine hormones and the nervous system in this communication are not fully integrated into existing frameworks.

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