Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway

Oct 18, 2014Molecular medicine reports

Lycopene reduces inflammation and cell death after heart attack by blocking the NF-kB signaling pathway

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Abstract

Lycopene (10 mg/kg/day) reduced the expression of key inflammatory and apoptotic markers in a mouse model of myocardial infarction.

Lycopene decreased the mRNA levels of fibrosis markers transforming growth factor-β1, collagen I, and collagen III.
Lycopene also lowered the mRNA expression of inflammatory markers tumor necrosis factor-α and interleukin-1β.
Protein expression of apoptotic markers caspase-3, -8, and -9 was reduced with lycopene treatment.
Activation of the NF-κB signaling pathway was inhibited by lycopene.
Ventricular remodeling post-myocardial infarction was attenuated following lycopene administration.

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Inflammatory response and cardiomyocyte apoptosis are important processes in ventricular remodeling post-myocardial infarction (MI) and may form the basic mechanisms in the development of chronic heart failure. The nuclear factor κB (NF-κB) signaling pathway could promote inflammation and apoptosis and it has been demonstrated that lycopene inhibits cigarette smoke extract-mediated NF-κB activation. Therefore, it was hypothesized that the NF-κB signaling pathway may be a key target of lycopene in the reversal of ventricular remodeling post MI. An MI model was established by left anterior descending coronary artery ligation in mice. Following ligation, the mice were administered with lycopene (10 mg/kg/day) or saline. The mice underwent echocardiography and were sacrificed after 4 weeks. The mRNA expression of fibrosis markers transforming growth factor-β1 (TGF-β1), collagen I and III and inflammatory markers tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were examined by quantitative polymerase chain reaction. The protein expression of apoptotic markers, including caspase-3, -8, -9 and activation of the NF-κB signaling pathway were analyzed by western blotting. Lycopene reduced the expression of TGF-β1, collagen I, collagen III, TNF-α, IL-1β, caspase-3, -8 and -9 and inhibited the activation of the NF-κB signaling pathway. The level of ventricular remodeling post-MI was also attenuated following treatment with lycopene. Lycopene may inhibit the NF-κB signaling pathway thereby reducing the inflammatory response and cardiomyocyte apoptosis post-MI, which could be a key mechanism of lycopene in attenuating ventricular remodeling.

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Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway

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