Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)

Mar 18, 2020Drug testing and analysis

Chemical and behavioral study of 1CP-LSD, a new type of lysergamide

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Abstract

1CP-LSD induces a head-twitch response in mice with an effective dose of 430.0 nmol/kg.

1CP-LSD is believed to be psychoactive in humans and may act as a prodrug for LSD.
Mass spectrometry and other analytical techniques confirmed the characterization of 1CP-LSD.
Incubation with human serum resulted in the formation of LSD from 1CP-LSD.
The head-twitch response induced by 1CP-LSD in mice suggests an LSD-like behavioral profile.
The effective dose for inducing head-twitch response in 1CP-LSD is comparable to previously tested 1P-LSD.

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Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lysergamides, did not exist before their appearance as research chemicals. 1-Cylopropanoyl-LSD (1CP-LSD) has recently emerged as a new addition to the group of lysergamide-based designer drugs and is believed to be psychoactive in humans. In this investigation, 1CP-LSD was subjected to detailed analytical characterizations including various mass spectrometry (MS) platforms, gas and liquid chromatography, nuclear magnetic resonance spectroscopy, solid phase and GC condensed phase infrared spectroscopy. Analysis by GC-MS also revealed the detection of artificially induced degradation products. Incubation of 1CP-LSD with human serum led to the formation of LSD, indicating that it may act as a prodrug for LSD in vivo, similar to other 1-acyl substituted lysergamides. The analysis of blotters and pellets is also included. 1CP-LSD also induces the head-twitch response (HTR) in C57BL/6 J mice, indicating that it produces an LSD-like behavioural profile. 1CP-LSD induced the HTR with an ED= 430.0 nmol/kg which was comparable to 1P-LSD (ED= 349.6 nmol/kg) investigated previously. Clinical studies are required to determine the potency and profile of the effects produced by 1CP-LSD in humans. 50 50

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Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1‐cyclopropanoyl‐d‐lysergic acid diethylamide (1CP‐LSD)

Abstract

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