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Abstract
Lysosomal dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD).
- Accumulation of amyloid-beta plaques and neurofibrillary tangles is characteristic of AD.
- The autophagy-lysosomal pathway is essential for degrading damaged organelles and proteins associated with AD.
- Lysosomes are crucial for breaking down dysfunctional proteins and maintaining cellular health.
- Genetic factors and abnormalities in acidification contribute to lysosomal dysfunction in AD.
- Microglial lysosomal dysfunction may play a role in the pathology of AD.
- Potential therapeutic strategies include activating lysosomal activity and regulating specific cellular pathways.
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