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Abstract
Essence
Suppressing hyperactivated lysosomes restored youthful molecular features and improved function in aged hematopoietic stem cells.
Evidence
This preclinical stem-cell study used single-cell transcriptomics, functional analyses, ex vivo v-ATPase inhibition of old HSCs, and in vivo repopulation assays showing over eightfold increased repopulation capacity.
Caveat
The intervention was tested ex vivo in aged HSCs with experimental repopulation endpoints, not as an in vivo therapy for elderly patients.
Simplified
Longevity & Aging