Clinical and translational medicineOct 22, 2026

A lysosomal protein helps protect the heart from injury after blood flow returns by promoting removal of damaged mitochondria through the NEDD4-LC3 pathway

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Oct 23, 2026

Abstract

Mitophagy is essential for mitochondrial quality control during myocardial ischemia-reperfusion injury.

Lysosomal protein transmembrane 5 (LAPTM5) is linked to cardiovascular disease and autophagy.
The specific role of LAPTM5 in cardiac mitophagy is not yet understood.
Understanding LAPTM5's function could provide insights into cardiac health during ischemia-reperfusion.

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