Lysosomes send signals that change gene activity to influence lifespan across generations

Lysosomal signaling may extend lifespan across generations by changing histone H3.3 expression and H3K79 methylation in Caenorhabditis elegans.

Animal mechanistic experiments in C. elegans tested lysosomal lipid signaling, lysosomal AMPK activation, lysosomal mTOR reduction, H3.3 transport, and germline H3K79 methyltransferase requirements for transgenerational longevity.

The findings come from a C. elegans model and do not establish that the same lysosome-epigenome mechanism controls longevity in humans.