m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Mar 19, 2020Cancer cell

Chemical Changes in RNA and Their Roles and Treatment Potential in Cancer

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

N-Methyladenosine (mA) RNA modification is a reversible epigenetic change that influences gene expression in eukaryotes.

mA modifications are found in both messenger RNAs and non-coding RNAs.
These modifications impact the stability and function of RNA molecules.
mA is associated with various critical biological processes, including cancer development.
The review highlights the roles of mA modifications in cancer pathogenesis and drug response.
Targeting mA regulators may offer new therapeutic strategies for cancer treatment.

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N-Methyladenosine (mA) RNA modification has emerged in recent years as a new layer of regulatory mechanism controlling gene expression in eukaryotes. As a reversible epigenetic modification found not only in messenger RNAs but also in non-coding RNAs, mA affects the fate of the modified RNA molecules and plays important roles in almost all vital bioprocesses, including cancer development. Here we review the up-to-date knowledge of the pathological roles and underlying molecular mechanism of mA modifications (in both coding and non-coding RNAs) in cancer pathogenesis and drug response/resistance, and discuss the therapeutic potential of targeting mA regulators for cancer therapy. 6 6 6 6 6

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m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Abstract

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