Machine learning finds cell recycling markers linked to small blood vessel damage in heart injury from blood flow loss and return

Ischemic heart disease (IHD) is a leading global cause of mortality.

• Reperfusion is necessary for treating ischemic cardiomyopathy but can cause additional damage.
• Myocardial ischemia/reperfusion (I/R) injury specifically affects the microvascular endothelium.
• The relationship between autophagy and damage to microvessels in myocardial I/R is not well understood.

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