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Abstract
The temporal regulation of macrophages during pregnancy is linked to complications such as recurrent pregnancy loss and preterm birth.
- Macrophage function is coordinated by a 'macrophage clock' that integrates molecular and metabolic signals during different stages of pregnancy.
- Circadian control and hormonal influences from the pineal gland play significant roles in regulating macrophage activities related to pregnancy.
- Key macrophage functions include modifying the uterine lining during implantation, aiding in spiral artery remodeling, and maintaining fetal tolerance.
- Environmental factors, like shift work and increased artificial light, may disrupt macrophage function and consequently affect pregnancy outcomes.
- Distinct metabolic patterns, including glycolysis and fatty acid metabolism, are associated with different phases of gestation and influence macrophage behavior.
- Disruption of temporal and metabolic signals in macrophages is correlated with various pregnancy complications.
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