Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells—Brief Report

Macrophages treated with senescent vascular smooth muscle cell conditioned media showed impaired oxLDL uptake and phagocytic activity.

• Senescent vascular smooth muscle cells have reduced capacity to scavenge oxidized low-density lipoprotein (oxLDL).
• Macrophages exposed to conditioned media from senescent cells exhibit diminished ability to uptake oxLDL.
• Phagocytic activity is also reduced in macrophages treated with media from senescent vascular smooth muscle cells.
• The ability of macrophages to clear senescent cells is impaired by factors released from senescent vascular smooth muscle cells.
• Senomorphic drugs can restore macrophage functions disrupted by the secretions of senescent vascular smooth muscle cells.

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