International journal of impotence research

Male sexual problems linked to GLP-1 receptor agonist medications: analysis of safety report data

Updated

Abstract

Among 182 cases identified, 43.9% involved patients using GLP-1 receptor agonists for diabetes.

  • GLP-1 receptor agonists are linked to reported instances of male sexual dysfunction, including orgasmic dysfunction, erectile dysfunction, and decreased libido.
  • The majority of affected patients were aged 40-60 years.
  • Exenatide was associated with 24.2% of reports, while semaglutide accounted for 21.4%.
  • Statistically significant results were noted (P < 0.0001), but the overall association with sexual dysfunction is considered weak based on low reporting odds ratios.
  • Monitoring of GLP-1 receptor agonist use may be necessary as their prescription increases, despite the low overall patient risk.

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Funding

Competing interests

Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All methods were performed in accordance with relevant guidelines and regulations. This study utilized publicly available, de-identified data from the FDA Adverse Event Reporting System (FAERS), and therefore did not involve direct interaction with human participants or identifiable private information. As such, the Stanford University School of Medicine Institutional Review Board determined that the study was exempt from review (IRB exemption granted; no reference number applicable for de-identified dataset studies). Because the research did not involve the collection of identifiable human data or images, informed consent to participate and consent for publication were not required.
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