An unexpected link: The role of mammary and gut microbiota on breast cancer development and management (Review)

Mar 31, 2021Oncology reports

Unexpected connection between breast and gut bacteria and breast cancer development and treatment

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Breast cancer affects 2.3 million women annually, highlighting its prevalence among female cancers.

Alterations in mammary and gut microbiota may play a role in breast cancer development and management.
Healthy breast tissue is associated with bacteria from specific phyla, while cancerous tissue shows different bacterial abundances.
Certain bacteria in healthy breast tissue may offer protective effects against breast cancer.
Distinct mammary microbiota profiles have been observed in different breast cancer subtypes, suggesting a specific microbial role in cancer progression.
Dysbiosis in gut microbiota has been linked to breast cancer, potentially affecting the production of beneficial metabolites and estrogen metabolism.

AI simplified

Breast cancer (BC) impacts 2.3 million women each year, making it the most frequent cancer diagnosed among the female population. An unexpected link has been discovered between BC and alterations in the mammary and gut microbiota, suggesting their possible role in BC development, prevention and management. Studies suggest a distinct microbiome in healthy breast tissue compared to BC tissue. The healthy breast tissue has been found to be mostly enriched with bacteria of the phylaand. However, certain bacteria are more abundant in cancerous tissues compared to adjacent non‑cancerous tissues in BC women or compared to the breast tissues of healthy women. On the other hand, bacteria such asspp. are increased in the breast tissues of healthy women compared to the cancerous tissues of BC women and may therefore have potential protective effects against BC. Additionally, preliminary studies propose that the mammary microbiota is distinct in the different subtypes of BC, proposing a specific role of microbes in the development of BC and suggesting their possible use as biomarkers. Similarly, dysbiosis in the gut microbiota has been further linked to BC since certain gut bacteria can alter the production of beneficial metabolites and disrupt estrogen metabolism in the gut. While still at its infancy, such unexpected links between breast and gut microbiota and BC propose possible alternatives with regards to the prevention but also management of BC such as through the use of probiotics. The current review is focused on evaluating the recent evidence regarding the association between mammary and gut microbiota and BC and discusses the most important bacteria involved. Proteobacteria, Firmicutes Actinobacteria Lactococcus

An unexpected link: The role of mammary and gut microbiota on breast cancer development and management (Review)

Abstract

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief