Management of obesity

Sep 26, 2024American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

How to Manage Obesity

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Abstract

Newer medications like semaglutide and tirzepatide can achieve a greater than 15% reduction in baseline weight.

Obesity is a prevalent chronic disease that poses significant health risks.
Most approved weight loss medications tend to have modest effects.
Optimal therapy selection should consider patient-specific factors and medication efficacy.
Multidisciplinary care teams may enhance the management of obesity through tailored treatment strategies.
The growing range of anti-obesity medications offers additional options alongside lifestyle changes and surgery.

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PURPOSE: This review summarizes the comprehensive management of obesity with a focus on the pharmacology, efficacy, and safety of anti-obesity medications.

SUMMARY: Obesity is a highly prevalent chronic disease with significant health risks, requiring a multifaceted approach to treatment. While most approved weight loss medications have modest effects, newer medications such as semaglutide and tirzepatide have shown greater than 15% reduction in baseline weight. Optimal selection of therapy requires taking into consideration patient factors, such as comorbidities and goals, and medication-related factors, including weight loss efficacy, contraindications, and improvements in cardiovascular risk. As the availability of anti-obesity medications increases, multidisciplinary care teams will play an important role in selecting optimal strategies for long-term health benefits in individuals with obesity.

CONCLUSION: The expanding array of anti-obesity medications provides valuable treatment options alongside lifestyle interventions and surgical approaches for managing obesity and reducing weight-related health risks. As this therapeutic area continues to grow, selecting optimal agents and educating patients on administration, monitoring, and potential adverse effects will be critical for improving overall outcomes.

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Management of obesity

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