Cardiovascular research

MAPK15 may cause heart cell aging and irregular heartbeat by increasing calcium overload in mitochondria through modifying Mcub protein

Updated

Abstract

The prevalence of atrial fibrillation (AF) is increasing rapidly with global aging.

  • Cellular senescence is a key factor contributing to the development of atrial fibrillation.
  • The mechanisms driving atrial cardiomyocyte senescence are not fully understood.
  • MAPK15 has been linked to regulating cell senescence in epithelial cells, but its role in heart cells is unclear.
  • This investigation focuses on the relationship between MAPK15, atrial cardiomyocyte senescence, and atrial fibrillation.

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