Materiobiology in the omics era

Multi-omics technologies provide insights into cellular responses to materials, revealing complex regulatory mechanisms across various biological levels.

• Single-cell transcriptomics and other omics approaches uncover cell heterogeneity and regulatory mechanisms in response to biomaterials.
• These technologies highlight transcriptional and epigenetic regulation, as well as genetic determinants influencing cellular responses.
• Protein and metabolic pathways, along with lipid and glycan remodeling, are revealed through multi-omics analysis in the context of biomaterial interactions.
• Multi-omics strategies aid in constructing bone organoids, which may serve as relevant models for studying bone development and repair.
• The integration of these findings supports the rational design of next-generation biomaterials for enhanced functionality in regenerative medicine.

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