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Abstract
Cellular mechanics may be a critical regulator of senescence, a fundamental driver of aging and age-related diseases.
- Cellular senescence is influenced by mechanical signals from the environment, affecting the structure and function of cells.
- Alterations in traction force, cytoskeletal organization, and nuclear mechanics are associated with senescence.
- Key pathways that respond to mechanical changes may play a role in the initiation and progression of senescence.
- Emerging mechanical methods could help identify senescent cells in various tissues.
- Mechanics-based interventions, such as mechanical stimulation and microenvironment remodeling, may offer therapeutic options for aging and regenerative medicine.
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