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Abstract
A prebiotic-based nutritional intervention was evaluated for its effects on clinical outcomes and gut microbiota in individuals with CDKL5 deficiency disorder.
- CDKL5 deficiency disorder is associated with severe neurodevelopmental impairment and treatment-resistant seizures.
- Alterations in the gut-brain axis may contribute to the pathophysiology of CDKL5 deficiency disorder.
- The study focused on the impact of a nutritional intervention targeting gut microbiota.
- Clinical outcomes, gut microbiota composition, and fatty acid profiles were assessed as part of the evaluation.
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