Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials

Aug 27, 2025BMC medicine

Effects of Mediterranean diet, exercise, and both combined on body weight and liver health in fatty liver disease linked to metabolism

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Abstract

The Mediterranean diet significantly reduced body weight by 2.38 kg in patients with metabolic dysfunction-associated liver disease.

The Mediterranean diet was associated with reductions in body mass index and waist circumference.
Aerobic and combined aerobic-resistance exercises led to a decrease in body weight compared to control.
Aerobic exercise significantly decreased waist circumference.
Resistance exercise was linked to a notable reduction in alanine aminotransferase levels.
Standardized methods for measuring outcomes are necessary for improving evidence on lifestyle changes.

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BACKGROUND: (MASLD) is a leading cause of liver-related morbidity and mortality. Lifestyle interventions like the Mediterranean diet (MD) and exercise are recommended for management, but the most effective lifestyle approach remains unclear.

METHODS: A comprehensive literature search was conducted in Embase, MEDLINE via Ovid, Cochrane Central, and Web of Science Core Collection from inception to April 1, 2025, without language restrictions. We included randomized controlled trials (RCTs) in adults with MASLD or metabolic dysfunction-associated steatohepatitis (MASH) assessing the MD and/or exercise interventions on anthropometric measures, liver enzymes, and indices or grades of liver steatosis and fibrosis. The mean difference and corresponding 95% confidence interval (CI) were pooled using a random-effects model. Risk of bias was assessed with ROB-2, and evidence certainty was evaluated using GRADE.

RESULTS: From a total of 4806 search results, 37 unique RCTs met the inclusion criteria, from which 11 assessed the MD and 27 exercise, either aerobic, resistance, or in combination, and two RCTs assessed the effect of the MD and exercise combination. Meta-analyses showed that the MD in comparison with the control significantly reduced body weight [weighted mean difference (WMD = - 2.38 kg, 95% CI - 4.11 to - 0.66), body mass index (WMD = - 0.70 kg/m, 95% CI = - 1.03 to - 0.36), waist circumference (WC) (WMD = - 1.56 cm, 95% CI - 3.02 to - 0.09), and alanine aminotransferase (ALT) (WMD = - 3.96 IU/L, 95% CI - 6.54 to - 1.38). Aerobic and combined aerobic-resistance exercises in comparison with the control group reduced body weight (WMD = - 1.56 kg, 95%CI - 2.31 to - 0.82; WMD = - 1.90 kg, 95%CI - 3.59 to - 0.22, respectively). In addition, aerobic exercise significantly decreased WC (WMD = - 2.14 IU/L, 95%CI - 2.87 to - 1.41) and resistance exercise reduced ALT (WMD = - 15.40 IU/L, 95%CI - 28.60 to - 2.20) in patients with MASLD/MASH compared to the control group. 2

CONCLUSIONS: The MD and aerobic exercise, whether alone or combined with resistance training, support weight loss and improve liver health in patients with MASLD/MASH. Standardized methods for measuring and reporting outcomes are essential to build robust evidence on the impact of lifestyle changes on clinical outcomes. TRIAL REGISTRATION: PROSPERO registration code. CRD42024577846.

Key numbers

-2.38 kg

Weight Reduction with Mediterranean Diet

Weighted mean difference compared to control group

-2.14 cm

Waist Circumference Reduction with Aerobic Exercise

Weighted mean difference compared to control group

-15.40 IU/L

ALT Level Reduction with Resistance Exercise

Weighted mean difference compared to control group

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Abstract

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