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MEKK3 bridges gut-brain communication and cerebral cavernous malformation pathogenesis
MEKK3 links gut-brain communication to development of brain blood vessel malformations
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Abstract
Cerebral cavernous malformation (CCM) is characterized by endothelial dysfunction and abnormal vascular structure.
- The gut microbiota is linked to cerebrovascular health and may impact the development of CCM.
- Dysbiosis can initiate systemic inflammation through pathways like lipopolysaccharide (LPS) -TLR4, short-chain fatty acids (SCFAs), and trimethylamine N-oxide (TMAO).
- These inflammatory responses may disrupt cerebrovascular function and the integrity of the blood-brain barrier.
- The gut-brain axis may influence the behavior of endothelial cells, affecting their proliferation, migration, and apoptosis.
- Existing studies indicate that the gut-brain axis could play a significant role in the pathological progression of CCM.
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