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Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision
Light-sensitive eye cells with different types and their role in seeing patterns
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Abstract
At least five distinct subtypes of intrinsically photosensitive retinal ganglion cells (ipRGCs) have been identified in a melanopsin reporter mouse model.
- IpRGCs have been found to be more abundant and diverse than previously known.
- These cells project more widely in the brain than previously appreciated.
- IpRGCs heavily innervate areas involved in object localization and discrimination, such as the superior colliculus and dorsal lateral geniculate nucleus.
- Mice that only rely on melanopsin for light detection can still discriminate visual stimuli and have measurable visual acuity.
- Nonclassical retinal photoreception may influence circuits and functions related to both luminance and spatial information.
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