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Melatonin: beyond circadian regulation - exploring its diverse physiological roles and therapeutic potential
Melatonin's roles beyond sleep timing and its possible health benefits
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Abstract
Melatonin is primarily involved in regulating the circadian rhythm system, crucial for the sleep-wake cycle.
- Melatonin's physiological functions have evolved from regulating skin pigmentation to various critical roles in mammals.
- Abnormal melatonin secretion is associated with the development of sleep disorders, which may increase the risk of chronic diseases.
- Melatonin may modulate oxidative stress, anti-inflammatory responses, and mitochondrial function.
- The hormone could influence energy metabolism, bone metabolism, nervous system regulation, and cardiovascular health at pharmacological doses.
- The article emphasizes the need to differentiate between melatonin's physiological and pharmacological effects.
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