Melatonin receptor 1-dependent gene expression in the mouse pars tuberalis as revealed by cDNA microarray analysis andin situhybridization

Melatonin regulates gene expression in the hypophyseal pars tuberalis through its type 1 receptors.

• The expression of the Tim gene is higher during the day compared to night in wild-type mice.
• No day/night differences in gene expression were found in mice lacking MT1 receptors.
• Melatonin application during the day affected Tim and Cry1 expression levels.
• The study indicates that melatonin may influence gene expression through both acute and long-term mechanisms.

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