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Membrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation
Cell-membrane-coated nanoparticles may reduce spine disc wear by lowering oxidative stress and boosting cell cleanup
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Abstract
The composite nanoparticle NPCM@CeO-RAPA significantly suppressed catabolic activity in a puncture-induced rat intervertebral disc degeneration model.
- Oxidative stress, mitochondrial dysfunction, and autophagy imbalance contribute to intervertebral disc degeneration.
- Cerium oxide (CeO) alleviated oxidative stress and partially restored mitochondrial function in vitro.
- Rapamycin (RAPA) individually modulated autophagy but was less effective alone.
- The combined treatment with NPCM@CeO-RAPA showed superior therapeutic effects compared to either component alone.
- In vivo studies indicated that NPCM@CeO-RAPA attenuated the progression of intervertebral disc degeneration.
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