AutophagyAug 21, 2026

Handling Cell Membrane Stress Using CASM

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Aug 22, 2026

Abstract

Conjugation of ATG8 to single membranes (CASM) may enable rapid responses to various membrane stresses.

Endolysosomal and secretory pathways face challenges like ion gradient loss and membrane disruption.
CASM is associated with stress-responsive targeting mechanisms that are distinct from traditional autophagy processes.
Recent advances show how cells sense membrane stress and initiate CASM.
CASM may facilitate localized cellular responses to specific stress conditions.

Simplified

Compartments of the endolysosomal and secretory pathways encounter diverse insults - from loss of ion gradients and osmotic imbalance to physical membrane disruption - creating a need for rapid, localized surveillance and response systems. Recent work demonstrates that conjugation of ATG8 to single membranes (CASM) provides such specificity via stress-responsive targeting mechanisms that recruit the ATG8 conjugation machinery through pathways distinct from macroautophagy/autophagy. Here, we review recent advances in how membrane stress is sensed, coupled to CASM initiation, and converted into downstream cellular responses.

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Handling Cell Membrane Stress Using CASM

Abstract

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