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Use of Mendelian Randomization to Evaluate the Effect of Atrial Fibrillation on Cardiovascular Diseases and Cardiac Death
Using genetic methods to study how irregular heartbeat relates to heart diseases and heart-related death
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Abstract
Atrial fibrillation is significantly associated with higher risks of various cardiovascular diseases and cardiac death.
- Genetically predicted atrial fibrillation is associated with a 24% increased risk of heart failure.
- The risk of ischaemic stroke increases by 21% in individuals with atrial fibrillation.
- Atrial fibrillation is linked to a 10% higher risk of transient ischaemic attack.
- There is a 9% increased risk of peripheral artery diseases associated with atrial fibrillation.
- Cardiac death risk is elevated by 8% in patients with atrial fibrillation.
- Hypertension is 6% more likely to occur in individuals with atrial fibrillation.
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Key numbers
1.24
Increase in heart failure risk
for heart failure linked to atrial fibrillation
1.21
Increase in ischaemic stroke risk
for ischaemic stroke linked to atrial fibrillation
1.06
Increase in hypertension risk
for hypertension linked to atrial fibrillation