Translational potential of mesenchymal stem cells in regenerative therapies for human diseases: challenges and opportunities

Aug 25, 2024Stem cell research & therapy

Potential and challenges of using mesenchymal stem cells for repairing human diseases

AI simplified

Regenerative Health on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

Stem cell-based therapy, particularly using multipotent (MSCs), shows potential in treating various human diseases.

MSCs are capable of self-renewal and can differentiate into multiple cell types.
Applications of MSCs include tissue regeneration, modulation of the immune system, and wound healing.
Recent advancements have improved the guidelines and quality control for MSC therapeutic applications.
MSCs from umbilical cord, bone marrow, and adipose tissue are being explored for treating conditions like pulmonary dysfunctions and neurological disorders.
The origin of MSCs may influence their function in therapeutic applications.

AI simplified

Advances in stem cell technology offer new possibilities for patients with untreated diseases and disorders. Stem cell-based therapy, which includes multipotent (MSCs), has recently become important in regenerative therapies. MSCs are multipotent progenitor cells that possess the ability to undergo in vitro self-renewal and differentiate into various mesenchymal lineages. MSCs have demonstrated promise in several areas, such as tissue regeneration, immunological modulation, anti-inflammatory qualities, and wound healing. Additionally, the development of specific guidelines and quality control methods that ultimately result in the therapeutic application of MSCs has been made easier by recent advancements in the study of MSC biology. This review discusses the latest clinical uses of MSCs obtained from the umbilical cord (UC), bone marrow (BM), or adipose tissue (AT) in treating various human diseases such as pulmonary dysfunctions, neurological disorders, endocrine/metabolic diseases, skin burns, cardiovascular conditions, and reproductive disorders. Additionally, this review offers comprehensive information regarding the clinical application of targeted therapies utilizing MSCs. It also presents and examines the concept of MSC tissue origin and its potential impact on the function of MSCs in downstream applications. The ultimate aim of this research is to facilitate translational research into clinical applications in regenerative therapies.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (PDF) ↗View full text (HTML) ↗

Translational potential of mesenchymal stem cells in regenerative therapies for human diseases: challenges and opportunities

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week: