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Mesial temporal tau pathology impacts basal forebrain degeneration in early Alzheimer's disease
Tau buildup in inner temporal brain areas is linked to early degeneration of the brain's memory-supporting system in Alzheimer's disease
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Abstract
In cognitively unimpaired individuals, the presence of both amyloid beta and tau was linked to reduced nucleus basalis of Meynert (Ch4) volume.
- Co-occurring amyloid beta and mesial-temporal (MTL) tau may reduce Ch4 volumes in cognitively unimpaired individuals.
- The association between MTL tau burden and Ch4 volume was only seen in those with established amyloid pathology.
- No relationship was found between MTL tau and hippocampal volume.
- This association persisted in individuals with mild cognitive impairment but was absent in those with Alzheimer's dementia.
- Findings suggest early Ch4 degeneration linked to Aβ and tau could support cognitive benefits of cholinergic therapies.
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