Full text is available at the source.
Messenger RNA delivery into Sertoli cells restores fertility to congenitally infertile male mice
Delivering messenger RNA to support cells restores fertility in infertile male mice
AI simplified
Abstract
mRNA delivery into mouse testes restored fertility in a genetic model of infertility.
- Injected mRNA was specifically expressed in Sertoli cells.
- An innate immune response was triggered, but spermatogenesis resumed without major side effects.
- Delivery of naked Cldn11 mRNA in mice with meiotic defects allowed progression from spermatocytes to spermatids.
- Fertile offspring with normal imprinting were produced via microinsemination.
- This approach may provide a safer alternative for treating male infertility by targeting testicular somatic cells.
AI simplified