Messenger RNA for progesterone receptor isoforms in the late-gestation rat uterus

Oct 22, 2002American journal of physiology. Endocrinology and metabolism

Messenger RNA levels of different progesterone receptor types in the late pregnancy rat uterus

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Abstract

PR-total mRNA increased significantly through late gestation, while PR-B mRNA remained unchanged.

  • The progesterone receptor has three isoforms: PR-A, PR-B, and PR-C, each with different effects.
  • The ratio of PR-total to PR-B peaked on the day before parturition.
  • Tamoxifen delayed parturition and inhibited the increase in PR-total mRNA without affecting PR-B levels.
  • RU-486 led to early parturition, which was associated with increased PR-total mRNA and unchanged PR-B levels.
  • Changes in PR isoforms during late gestation may be influenced by estrogen and progesterone.

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